Research workbench
Crystal structure of importin 13 - UBC9 complex
Analyse Crystal structure of importin 13 - UBC9 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2XWU
- Type
- protein
- Length
- 1,068 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sumo-conjugating enzyme UBC9; IMPORTIN13
- EC
- 6.3.2.19
- UniProt
- P63279, O94829
- Pockets
- 6 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sumo-conjugating enzyme UBC9 (EC 6.3.2.19) | protein | 158 | 35% helix, 20% strand | P63279 |
| B | IMPORTIN13 | protein | 910 | 79% helix, 0% strand | O94829 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 784 | 0.80 | 0.84 | 72 | empty |
| 2 | 292 | 0.72 | 0.86 | 42 | empty |
| 3 | 105 | 0.64 | 0.88 | 35 | empty |
| 4 | 128 | 0.57 | 0.83 | 23 | empty |
| 5 | 139 | 0.39 | 0.73 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1418 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2XWU · Crystal structure of importin 13 - UBC9 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P63279 · AlphaFold monomer V2.0 prediction for sumo-conjugating enzyme UBC9 (P63279) · a predicted model of the same protein · chain A against A, TM-score 0.99
- O94829 · AlphaFold monomer V2.0 prediction for importin-13 (O94829) · a predicted model of the same protein · chain B against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63279
- Every structure of UniProt O94829
- Elsewhere: RCSB PDB 2XWU · PDBe 2XWU · UniProt P63279 · UniProt O94829
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