Research workbench
The mediator MED25 activator interaction domain: structure and cooperative binding of VP16 subdomains
Analyse The mediator MED25 activator interaction domain: structure and cooperative… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2XNF
- Type
- protein
- Length
- 159 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mediator of RNA polymerase II transcription subunit 25
- UniProt
- Q71SY5
- Pockets
- 2 · best druggability 0.36
Structure
solution nmr · 1 distinct chain · 28% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mediator of RNA polymerase II transcription subunit 25 | protein | 159 | 28% helix, 36% strand | Q71SY5 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.36 | 0.77 | 19 | empty |
| 2 | 71 | 0.32 | 0.74 | 13 | empty |
Compared structures
- 2XNF · The Mediator Med25 activator interaction domain: Structure and cooperative binding of… · the same entry in another collection · chain A against A, TM-score 1.00
- Q71SY5 · AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit… · a predicted model of the same protein · chain A against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q71SY5
- Elsewhere: RCSB PDB 2XNF · PDBe 2XNF · UniProt Q71SY5
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