UniProt Q71SY5
Mediator of RNA polymerase II transcription subunit 25 (Q71SY5)
Mediator of RNA polymerase II transcription subunit 25 (UniProt Q71SY5): 10 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q71SY5
- Protein
- Mediator of RNA polymerase II transcription subunit 25
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 3 · 2 records with a druggable one
Structures
11 records of Q71SY5 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KY6 | Structure of ARC92VBD/MED25ACID | solution nmr | A | — | — |
| 2KY6 | Structure of ARC92VBD/MED25ACID | solution nmr | A | — | — |
| 2L23 | NMR structure of the ACID (ACtivator Interacting Domain) of the human mediator Med25 protein | solution nmr | A | — | — |
| 2L6U | Solution NMR Structure of Med25(391-543) Comprising the Activator-Interacting Domain (ACID) of… | solution nmr | A | — | — |
| 2L6U | Solution NMR structure of MED25(391-543) comprising the activator- interacting domain (acid) of… | solution nmr | A | — | — |
| 2XNF | The Mediator Med25 activator interaction domain: Structure and cooperative binding of VP16… | solution nmr | A | — | — |
| 2XNF | The mediator MED25 activator interaction domain: structure and cooperative binding of VP16… | solution nmr | A | — | — |
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | Y | — | 2 (best 0.86) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | Y | — | — |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | y | — | 1 (best 0.87) |
| Q71SY5 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 25… | predicted | A | — | — |
Experiment against prediction
- 8GXQ chain y against the predicted model Q71SY5: TM-score 0.97, RMSD 1.02 Å
- 7EMF chain Y against the predicted model Q71SY5: TM-score 0.97, RMSD 1.02 Å
- 7EMF chain Y against the predicted model Q71SY5: TM-score 0.97, RMSD 1.02 Å
- 2L6U chain A against the predicted model Q71SY5: TM-score 0.83, RMSD 2.30 Å
- 2L6U chain A against the predicted model Q71SY5: TM-score 0.83, RMSD 2.30 Å
- 2L23 chain A against the predicted model Q71SY5: TM-score 0.81, RMSD 2.66 Å
- 2KY6 chain A against the predicted model Q71SY5: TM-score 0.81, RMSD 2.41 Å
- 2KY6 chain A against the predicted model Q71SY5: TM-score 0.81, RMSD 2.41 Å
- 2XNF chain A against the predicted model Q71SY5: TM-score 0.78, RMSD 2.60 Å
- 2XNF chain A against the predicted model Q71SY5: TM-score 0.78, RMSD 2.60 Å
Elsewhere
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