Research workbench
Structure and metal-loading of a soluble periplasm cupro-protein: cu- cuca-closed
Analyse Structure and metal-loading of a soluble periplasm cupro-protein: cu… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2XLA
- Type
- protein
- Length
- 936 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SLL1785 protein
- UniProt
- P73600
- Ligands
- URE, CU
- Pockets
- 4 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SLL1785 protein | protein | 233 | 18% helix, 34% strand | P73600 |
| B, D | SLL1785 protein | protein | 234 | 18% helix, 35% strand | P73600 |
| C | SLL1785 protein | protein | 235 | 17% helix, 35% strand | P73600 |
Ligands and binding sites
- URE · Urea · ligand · 4 copies · chains A, B, C, D
- CU · Copper (II) ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 674 | 0.74 | 0.80 | 55 | empty |
| 2 | 581 | 0.74 | 0.81 | 50 | empty |
| 3 | 518 | 0.63 | 0.75 | 45 | empty |
| 4 | 115 | 0.37 | 0.74 | 22 | empty |
Interfaces
3 interfaces between chains.
- A–B · 873 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 857 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 316 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 2XLA · Structure and metal-loading of a soluble periplasm cupro-protein: Cu- CucA-closed · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P73600
- Elsewhere: RCSB PDB 2XLA · PDBe 2XLA · UniProt P73600
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.