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Structure of putative deoxyribonuclease TATDN1 isoform a

Analyse Structure of putative deoxyribonuclease TATDN1 isoform a in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2XIO
Type
protein
Length
293 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Putative deoxyribonuclease TATDN1
EC
3.1.21.-
UniProt
Q6P1N9
Ligands
NA, NI
Pockets
2 · best druggability 0.47

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 17% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
APutative deoxyribonuclease TATDN1 (EC 3.1.21.-)protein29346% helix, 17% strandQ6P1N9

Ligands and binding sites

  • NA · Sodium ion · metal · chains A
  • NI · Nickel (II) ion · metal · chains A
  • EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12180.470.7425EDO
2940.370.7520empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

  • 2XIO · Structure of putative deoxyribonuclease TATDN1 isoform a · the same entry in another collection · chain A against A, TM-score 1.00
  • Q6P1N9 · AlphaFold monomer V2.0 prediction for putative deoxyribonuclease TATDN1 (Q6P1N9) · a predicted model of the same protein · chain A against A, TM-score 1.00

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