Research workbench
Crystal structure of mevalonate kinase from methicillin- resistant staphylococcus aureus MRSA252
Analyse Crystal structure of mevalonate kinase from methicillin- resistant… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2X7I
- Type
- protein
- Length
- 295 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mevalonate kinase
- UniProt
- Q6GJ78
- Ligands
- CL
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mevalonate kinase | protein | 295 | 39% helix, 26% strand | Q6GJ78 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 106 | 0.67 | 0.90 | 15 | empty |
| 2 | 145 | 0.60 | 0.85 | 25 | CIT |
| 3 | 75 | 0.53 | 0.85 | 20 | empty |
| 4 | 52 | 0.36 | 0.79 | 16 | empty |
Compared structures
- 2X7I · Crystal structure of mevalonate kinase from methicillin-resistant Staphylococcus aureus… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GJ78
- Elsewhere: RCSB PDB 2X7I · PDBe 2X7I · UniProt Q6GJ78
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