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Human foamy virus integrase - catalytic core.

Analyse Human foamy virus integrase - catalytic core. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2X78
Type: protein
Length: 530 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Integrase
UniProt: P14350
Pockets: 11 · best druggability 0.75

Structure

x-ray diffraction · 3 distinct chains · 42% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Integrase	protein	171	43% helix, 19% strand	P14350
B	Integrase	protein	176	42% helix, 17% strand	P14350
C	Integrase	protein	183	42% helix, 16% strand	P14350

Pockets

11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	78	0.75	0.97	22	empty
2	353	0.74	0.85	36	empty
3	376	0.66	0.79	50	empty
4	127	0.58	0.84	18	empty
5	310	0.57	0.76	44	empty

Interfaces

2 interfaces between chains.

A–B · 1424 Å² buried · 16 hydrogen bonds · protein-protein
B–C · 576 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

2X78 · Human foamy virus integrase - catalytic core. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14350
Elsewhere: RCSB PDB 2X78 · PDBe 2X78 · UniProt P14350

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