Tet repressor class D in complex with 7-chlor-2-cyano-iso- tetracycline

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Ligands and binding sites

• 2TC · (4s,4as,6s,8as)-6-[(1S)-7-chloro-4-hydroxy-1-methyl-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-4-(dimethylamino)-3,8A-dihydroxy-1,8-dioxo-1,4,4A,5,6,7,8,8A-octahydronaphthalene-2-carbonitrile · ligand · chains A
• CL · Chloride ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 2X6O · Tet Repressor class D in complex with 7-chlor-2-cyano-iso- tetracycline · the same entry in another collection · chain A against A, TM-score 1.00
• P0ACT4 · AlphaFold monomer V2.0 prediction for tetracycline repressor protein class D (P0ACT4) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P0ACT4
• Elsewhere: RCSB PDB 2X6O · PDBe 2X6O · UniProt P0ACT4