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Structure of the proteolytic domain of the human mitochondrial lon protease
Analyse Structure of the proteolytic domain of the human mitochondrial lon protease in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2X36
- Type
- protein
- Length
- 1,100 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lon protease homolog, mitochondrial
- EC
- 3.4.21.-
- UniProt
- P36776
- Pockets
- 15 · best druggability 0.80
Structure
x-ray diffraction · 6 distinct chains · 39% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lon protease homolog, mitochondrial (EC 3.4.21.-) | protein | 190 | 38% helix, 25% strand | P36776 |
| B | Lon protease homolog, mitochondrial (EC 3.4.21.-) | protein | 180 | 39% helix, 25% strand | P36776 |
| C | Lon protease homolog, mitochondrial (EC 3.4.21.-) | protein | 192 | 37% helix, 24% strand | P36776 |
| D | Lon protease homolog, mitochondrial (EC 3.4.21.-) | protein | 178 | 41% helix, 25% strand | P36776 |
| E | Lon protease homolog, mitochondrial (EC 3.4.21.-) | protein | 181 | 40% helix, 27% strand | P36776 |
| F | Lon protease homolog, mitochondrial (EC 3.4.21.-) | protein | 179 | 41% helix, 27% strand | P36776 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1106 | 0.80 | 0.81 | 80 | empty |
| 2 | 290 | 0.70 | 0.84 | 46 | empty |
| 3 | 93 | 0.62 | 0.89 | 27 | empty |
| 4 | 317 | 0.60 | 0.78 | 36 | empty |
| 5 | 198 | 0.54 | 0.78 | 23 | empty |
Interfaces
8 interfaces between chains.
- C–D · 812 Ų buried · 13 hydrogen bonds · protein-protein
- A–E · 811 Ų buried · 8 hydrogen bonds · protein-protein
- C–F · 791 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 777 Ų buried · 18 hydrogen bonds · protein-protein
- C–E · 456 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2X36 · Structure of the proteolytic domain of the Human Mitochondrial Lon protease · the same entry in another collection · chain F against F, TM-score 1.00
- P36776 · AlphaFold monomer V2.0 prediction for lon protease homolog, mitochondrial (P36776) · a predicted model of the same protein · chain F against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36776
- Elsewhere: RCSB PDB 2X36 · PDBe 2X36 · UniProt P36776
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