Research workbench
Crystal structure of the complete EPHA2 ectodomain in complex with ephrin A5 receptor binding domain
Analyse Crystal structure of the complete EPHA2 ectodomain in complex with ephrin A5… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2X11
- Type
- protein
- Length
- 626 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ephrin type-a receptor 2; Ephrin-A5
- EC
- 2.7.10.1
- UniProt
- P29317, P52803
- Pockets
- 5 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ephrin type-a receptor 2 (EC 2.7.10.1) | protein | 488 | 4% helix, 44% strand | P29317 |
| B | Ephrin-A5 | protein | 138 | 7% helix, 34% strand | P52803 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 233 | 0.56 | 0.78 | 43 | empty |
| 2 | 61 | 0.48 | 0.84 | 13 | empty |
| 3 | 93 | 0.43 | 0.79 | 22 | empty |
| 4 | 85 | 0.41 | 0.78 | 18 | empty |
| 5 | 107 | 0.37 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1034 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 disulfide (disulfide).
Compared structures
- 2X11 · Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor… · the same entry in another collection · chain A against A, TM-score 1.00
- P52803 · AlphaFold monomer V2.0 prediction for ephrin-A5 (P52803) · a predicted model of the same protein · chain B against A, TM-score 0.96
- P29317 · AlphaFold monomer V2.0 prediction for ephrin type-a receptor 2 (P29317) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29317
- Every structure of UniProt P52803
- Elsewhere: RCSB PDB 2X11 · PDBe 2X11 · UniProt P29317 · UniProt P52803
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