Research workbench
Clostridium perfringens alpha-toxin strain NCTC8237 mutant T74I
Analyse Clostridium perfringens alpha-toxin strain NCTC8237 mutant T74I in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WXU
- Type
- protein
- Length
- 361 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phospholipase C
- EC
- 3.1.4.3
- UniProt
- Q0TV31
- Ligands
- CD, CA, ZN
- Pockets
- 4 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phospholipase C (EC 3.1.4.3) | protein | 361 | 45% helix, 17% strand | Q0TV31 |
Ligands and binding sites
- CD · Cadmium ion · metal · 7 copies · chains A
- CA · Calcium ion · metal · 5 copies · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 120 | 0.60 | 0.86 | 30 | empty |
| 2 | 162 | 0.52 | 0.79 | 27 | empty |
| 3 | 71 | 0.40 | 0.79 | 13 | empty |
| 4 | 92 | 0.39 | 0.77 | 20 | CD |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q0TV31
- Elsewhere: RCSB PDB 2WXU · PDBe 2WXU · UniProt Q0TV31
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