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The crystal structure of the murine class ia pi 3-kinase P110DELTA.
Analyse The crystal structure of the murine class ia pi 3-kinase P110DELTA. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WXR
- Type
- protein
- Length
- 822 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- EC
- 2.7.1.153
- UniProt
- Q3UDT3
- Pockets
- 13 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) | protein | 822 | 47% helix, 18% strand | Q3UDT3 |
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1141 | 0.80 | 0.82 | 75 | empty |
| 2 | 348 | 0.71 | 0.83 | 51 | empty |
| 3 | 605 | 0.66 | 0.76 | 61 | empty |
| 4 | 150 | 0.63 | 0.85 | 24 | empty |
| 5 | 312 | 0.61 | 0.78 | 37 | empty |
Compared structures
- 2WXR · The crystal structure of the murine class IA PI 3-kinase p110delta. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3UDT3
- Elsewhere: RCSB PDB 2WXR · PDBe 2WXR · UniProt Q3UDT3
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