Research workbench
Crystal structure of the titin M10-obscurin like 1 ig complex in space group P1
Analyse Crystal structure of the titin M10-obscurin like 1 ig complex in space group P1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WWM
- Type
- protein
- Length
- 393 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Obscurin-like protein 1; Titin
- EC
- 2.7.11.1
- UniProt
- O75147, Q8WZ42
- Pockets
- 2 · best druggability 0.41
Structure
x-ray diffraction · 4 distinct chains · 2% helix, 62% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Obscurin-like protein 1 | protein | 98 | 0% helix, 61% strand | O75147 |
| D | Titin (EC 2.7.11.1) | protein | 100 | 3% helix, 62% strand | Q8WZ42 |
| O | Obscurin-like protein 1 | protein | 97 | 3% helix, 63% strand | O75147 |
| T | Titin (EC 2.7.11.1) | protein | 98 | 3% helix, 60% strand | Q8WZ42 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 115 | 0.41 | 0.76 | 21 | empty |
| 2 | 95 | 0.34 | 0.74 | 15 | empty |
Interfaces
5 interfaces between chains.
- O–T · 670 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 636 Ų buried · 13 hydrogen bonds · protein-protein
- D–O · 369 Ų buried · 3 hydrogen bonds · protein-protein
- D–T · 66 Ų buried · 0 hydrogen bonds · protein-protein
- C–T · 45 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2WWM · Crystal structure of the Titin M10-Obscurin like 1 Ig complex in space group P1 · the same entry in another collection · chain C against C, TM-score 1.00
- O75147 · AlphaFold monomer V2.0 prediction for obscurin-like protein 1 (O75147) · a predicted model of the same protein · chain O against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75147
- Every structure of UniProt Q8WZ42
- Elsewhere: RCSB PDB 2WWM · PDBe 2WWM · UniProt O75147 · UniProt Q8WZ42
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