Research workbench
Crystal structure of human erythropoietin complexed to its receptor at 1.9 ångströms
Analyse Crystal structure of human erythropoietin complexed to its receptor at 1.9… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1EER
- Type
- protein
- Length
- 592 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Erythropoietin; Erythropoietin receptor
- UniProt
- P01588, P19235
- Pockets
- 7 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Erythropoietin | protein | 166 | 64% helix, 8% strand | P01588 |
| B, C | Erythropoietin receptor | protein | 213 | 10% helix, 45% strand | P19235 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 225 | 0.58 | 0.80 | 39 | empty |
| 2 | 157 | 0.42 | 0.74 | 24 | empty |
| 3 | 94 | 0.41 | 0.77 | 18 | empty |
| 4 | 50 | 0.33 | 0.78 | 18 | empty |
| 5 | 88 | 0.33 | 0.74 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1048 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 733 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 47 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1EER · Crystal structure of human erythropoietin complexed to its receptor at 1.9 ångströms · the same entry in another collection · chain B against B, TM-score 1.00
- P19235 · AlphaFold monomer V2.0 prediction for erythropoietin receptor (P19235) · a predicted model of the same protein · chain C against A, TM-score 0.95
- P01588 · AlphaFold monomer V2.0 prediction for erythropoietin (P01588) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01588
- Every structure of UniProt P19235
- Elsewhere: RCSB PDB 1EER · PDBe 1EER · UniProt P01588 · UniProt P19235
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