UniProt P19235
Erythropoietin receptor (P19235)
Erythropoietin receptor (UniProt P19235): 36 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 50 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P19235
- Protein
- Erythropoietin receptor
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 50 · 8 records with a druggable one
Structures
37 records of P19235 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CN4 | Erythropoietin complexed with extracellular domains of erythropoietin receptor | x-ray diffraction | A, B | — | — |
| 1CN4 | Erythropoietin complexed with extracellular domains of erythropoietin receptor | x-ray diffraction | A, B | — | — |
| 1EBA | Complex between the extracellular domain of erythropoietin (epo) receptor [ebp] and an inactive… | x-ray diffraction | A, B | — | — |
| 1EBA | Complex between the extracellular domain of erythropoietin (epo) receptor [ebp] and an inactive… | x-ray diffraction | A, B | — | — |
| 1EBP | Complex between the extracellular domain of erythropoietin (epo) receptor [ebp] and an agonist… | x-ray diffraction | A, B | — | — |
| 1EBP | Complex between the extracellular domain of erythropoietin (epo) receptor [ebp] and an agonist… | x-ray diffraction | A, B | — | — |
| 1EER | Crystal structure of human erythropoietin complexed to its receptor at 1.9 ångströms | x-ray diffraction | B, C | — | — |
| 1EER | Crystal structure of human erythropoietin complexed to its receptor at 1.9 ångströms | x-ray diffraction | B, C | — | — |
| 1ERN | Native structure of the extracellular domain of erythropoietin (epo) receptor [ebp] | x-ray diffraction | A, B | — | — |
| 1ERN | Native structure of the extracellular domain of erythropoietin (epo) receptor [ebp] | x-ray diffraction | A, B | — | — |
| 2JIX | Crystal structure of ABT-007 FAB fragment with the soluble domain of EPO receptor | x-ray diffraction | B, C, E | — | — |
| 2JIX | Crystal structure of abt-007 Fab fragment with the soluble domain of epo receptor | x-ray diffraction | B, C, E | — | — |
| 2MV6 | Solution structure of the transmembrane domain and the juxta-membrane domain of the Erythropoietin… | solution nmr | A | — | — |
| 2MV6 | Solution structure of the transmembrane domain and the juxta-membrane domain of the erythropoietin… | solution nmr | A | — | — |
| 4Y5V | Diabody 305 complex with EpoR | x-ray diffraction | C, F, I | — | 14 (best 0.78) |
| 4Y5V | Diabody 305 complex with epor | x-ray diffraction | C, F, I | — | — |
| 4Y5X | Diabody 305 complex with EpoR | x-ray diffraction | C, F, I, L | — | — |
| 4Y5X | Diabody 305 complex with epor | x-ray diffraction | C, F, I, L | — | — |
| 4Y5Y | Diabody 330 complex with EpoR | x-ray diffraction | C, F | — | — |
| 4Y5Y | Diabody 330 complex with epor | x-ray diffraction | C, F | — | — |
| 6E2Q | Structure of human JAK2 FERM/SH2 in complex with Erythropoietin Receptor | x-ray diffraction | M, N, O, P | — | 9 (best 0.73) |
| 6E2Q | Structure of human JAK2 FERM/SH2 in complex with erythropoietin receptor | x-ray diffraction | M, N, O, P | — | — |
| 6MOE | Monomeric DARPin E2 complex with EpoR | x-ray diffraction | C, D | PO4 | 6 (best 0.71) |
| 6MOE | Monomeric darpin E2 complex with epor | x-ray diffraction | C, D | PO4 | — |
| 6MOF | Monomeric DARPin G2 complex with EpoR | x-ray diffraction | B | — | 2 (best 0.67) |
| 6MOF | Monomeric darpin G2 complex with epor | x-ray diffraction | B | — | — |
| 6MOH | Dimeric DARPin C_R3 complex with EpoR | x-ray diffraction | C, D | PO4 | 7 (best 0.73) |
| 6MOH | Dimeric darpin C_R3 complex with epor | x-ray diffraction | C, D | PO4 | — |
| 6MOI | Dimeric darpin C_ANGLE_R5 complex with epor | x-ray diffraction | B | SO4, MG | — |
| 6MOJ | Dimeric DARPin A_angle_R5 complex with EpoR | x-ray diffraction | B | — | 1 (best 0.69) |
| 6MOJ | Dimeric darpin A_ANGLE_R5 complex with epor | x-ray diffraction | B | — | — |
| 6MOK | Dimeric DARPin A_distance_R7 complex with EpoR | x-ray diffraction | B | — | 4 (best 0.66) |
| 6MOK | Dimeric darpin A_DISTANCE_R7 complex with epor | x-ray diffraction | B | — | — |
| 6MOL | Monoextended DARPin M_R12 complex with EpoR | x-ray diffraction | B, C | — | 6 (best 0.70) |
| 6MOL | Monoextended darpin M_R12 complex with epor | x-ray diffraction | B, C | — | — |
| 8VUI | Structure of FabS1CE-EPR-1, an elbow-locked Fab, in complex with the erythropoeitin receptor | x-ray diffraction | D | NAG, NH4, CL | 1 (best 0.43) |
| P19235 | AlphaFold monomer V2.0 prediction for erythropoietin receptor (P19235) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4Y5X chain C against the predicted model P19235: TM-score 0.97, RMSD 0.97 Å
- 4Y5X chain C against the predicted model P19235: TM-score 0.97, RMSD 0.97 Å
- 8VUI chain D against the predicted model P19235: TM-score 0.97, RMSD 1.03 Å
- 4Y5X chain L against the predicted model P19235: TM-score 0.97, RMSD 1.08 Å
- 4Y5X chain L against the predicted model P19235: TM-score 0.97, RMSD 1.08 Å
- 4Y5X chain I against the predicted model P19235: TM-score 0.97, RMSD 1.07 Å
- 4Y5X chain I against the predicted model P19235: TM-score 0.97, RMSD 1.07 Å
- 1CN4 chain A against the predicted model P19235: TM-score 0.97, RMSD 1.17 Å
- 1CN4 chain A against the predicted model P19235: TM-score 0.97, RMSD 1.17 Å
- 4Y5X chain F against the predicted model P19235: TM-score 0.96, RMSD 1.17 Å
Elsewhere
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