MolNFT v1 · #157104 · protein
Monoextended darpin M_R12 complex with epor
6MOL · Monoextended darpin R12 (M_R12): “Monoextended darpin M_R12 complex with epor”. X-ray diffraction, 6 pockets (best druggability 0.70). MolNFT v1 #157104 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MOL
- Type
- protein
- Length
- 876 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monoextended darpin R12 (M_R12); Erythropoietin receptor
- UniProt
- P19235
- Pockets
- 6 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 33% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Monoextended darpin R12 (M_R12) | protein | 452 | 55% helix, 0% strand | — |
| B | Erythropoietin receptor | protein | 213 | 9% helix, 45% strand | P19235 |
| C | Erythropoietin receptor | protein | 211 | 8% helix, 44% strand | P19235 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 334 | 0.70 | 0.83 | 39 | empty |
| 2 | 589 | 0.70 | 0.79 | 67 | empty |
| 3 | 176 | 0.54 | 0.80 | 25 | GOL |
| 4 | 148 | 0.40 | 0.73 | 30 | empty |
| 5 | 94 | 0.39 | 0.76 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 995 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 875 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 31 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19235
- Elsewhere: RCSB PDB 6MOL · PDBe 6MOL · UniProt P19235
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