Research workbench
Crystal structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from saccharomyces cerevisiae complexed with NAD
Analyse Crystal structure of the NAD-dependent 5,10-methylenetetrahydrofolate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1EE9
- Type
- protein
- Length
- 317 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5,10-methylenetetrahydrofolate dehydrogenase
- EC
- 1.5.1.15
- UniProt
- Q02046
- Ligands
- NAD
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5,10-methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15) | protein | 317 | 39% helix, 19% strand | Q02046 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 469 | 0.73 | 0.82 | 42 | NAD |
| 2 | 208 | 0.53 | 0.78 | 21 | empty |
| 3 | 61 | 0.33 | 0.76 | 13 | empty |
Compared structures
- 1EE9 · Crystal structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from… · the same entry in another collection · chain A against A, TM-score 1.00
- Q02046 · AlphaFold monomer V2.0 prediction for methylenetetrahydrofolate dehydrogenase [NAD(+)]… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02046
- Elsewhere: RCSB PDB 1EE9 · PDBe 1EE9 · UniProt Q02046
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.