Research workbench
Yeast karyopherin (importin) alpha in a complex with a nucleoplasmin nls peptide
Analyse Yeast karyopherin (importin) alpha in a complex with a nucleoplasmin nls peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1EE5
- Type
- protein
- Length
- 440 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Karyopherin alpha; Nucleoplasmin
- UniProt
- Q02821, P05221
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Karyopherin alpha | protein | 421 | 74% helix, 0% strand | Q02821 |
| B | Nucleoplasmin | protein | 19 | 0% helix, 0% strand | P05221 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 103 | 0.51 | 0.82 | 22 | empty |
| 2 | 61 | 0.36 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1372 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 1EE5 · Yeast karyopherin (importin) alpha in a complex with a nucleoplasmin nls peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q02821 · AlphaFold monomer V2.0 prediction for importin subunit alpha (Q02821) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P05221 · AlphaFold monomer V2.0 prediction for nucleoplasmin (P05221) · a predicted model of the same protein · chain B against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02821
- Every structure of UniProt P05221
- Elsewhere: RCSB PDB 1EE5 · PDBe 1EE5 · UniProt Q02821 · UniProt P05221
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