Research workbench
Structure of the ATP-sensitive inward rectifier potassium channel from magnetospirillum magnetotacticum
Analyse Structure of the ATP-sensitive inward rectifier potassium channel from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WLK
- Type
- protein
- Length
- 582 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-sensitive inward rectifier potassium channel 10
- Ligands
- SPM, K, CL
- Pockets
- 8 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 27% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | ATP-sensitive inward rectifier potassium channel 10 | protein | 291 | 27% helix, 33% strand | — |
Ligands and binding sites
- SPM · Spermine · ligand · chains A, B
- K · Potassium ion · metal · 5 copies · chains A, B
- CL · Chloride ion · ion · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 522 | 0.76 | 0.83 | 46 | CL |
| 2 | 213 | 0.58 | 0.80 | 27 | empty |
| 3 | 228 | 0.53 | 0.76 | 31 | empty |
| 4 | 246 | 0.50 | 0.75 | 45 | empty |
| 5 | 83 | 0.41 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 2492 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 2WLK · Structure of the ATP-sensitive inward rectifier potassium channel from magnetospirillum… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2WLK · PDBe 2WLK
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