Research workbench
Crystal structure of the human ionotropic glutamate receptor GLUR2 atd region at 4.1 a resolution
Analyse Crystal structure of the human ionotropic glutamate receptor GLUR2 atd region… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WJX
- Type
- protein
- Length
- 1,089 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2
- UniProt
- P42262
- Pockets
- 13 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Glutamate receptor 2 | protein | 363 | 35% helix, 23% strand | P42262 |
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 907 | 0.84 | 0.86 | 92 | empty |
| 2 | 534 | 0.76 | 0.83 | 43 | empty |
| 3 | 123 | 0.67 | 0.89 | 25 | empty |
| 4 | 404 | 0.66 | 0.79 | 35 | empty |
| 5 | 352 | 0.65 | 0.80 | 33 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1492 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 409 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 2WJX · Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 4.1 A… · the same entry in another collection · chain A against A, TM-score 1.00
- P42262 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P42262) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42262
- Elsewhere: RCSB PDB 2WJX · PDBe 2WJX · UniProt P42262
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