Research workbench
Structure and function of the feob G-domain from methanococcus jannaschii
Analyse Structure and function of the feob G-domain from methanococcus jannaschii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WJG
- Type
- protein
- Length
- 343 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferrous iron transport protein B homolog; Polyalanine
- UniProt
- Q57986
- Ligands
- GDP
- Pockets
- 2 · best druggability 0.31
Structure
x-ray diffraction · 3 distinct chains · 38% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ferrous iron transport protein B homolog | protein | 170 | 39% helix, 27% strand | Q57986 |
| B | Ferrous iron transport protein B homolog | protein | 166 | 37% helix, 27% strand | Q57986 |
| C | Polyalanine | protein | 7 | 43% helix, 0% strand | — |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.31 | 0.75 | 18 | empty |
| 2 | 55 | 0.29 | 0.75 | 12 | GDP |
Interfaces
2 interfaces between chains.
- A–B · 634 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 25 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2WJG · Structure and function of the FeoB G-domain from Methanococcus jannaschii · the same entry in another collection · chain A against A, TM-score 1.00
- Q57986 · AlphaFold monomer V2.0 prediction for FE(2+) transporter feob (Q57986) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q57986
- Elsewhere: RCSB PDB 2WJG · PDBe 2WJG · UniProt Q57986
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