Research workbench
Smc hinge heterodimer (mouse)
Analyse Smc hinge heterodimer (mouse) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WD5
- Type
- protein
- Length
- 368 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosomes protein 1A; Structural maintenance of chromosomes…
- UniProt
- Q9CU62, Q9CW03
- Pockets
- 3 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Structural maintenance of chromosomes protein 1A | protein | 177 | 48% helix, 18% strand | Q9CU62 |
| B | Structural maintenance of chromosomes protein 3 | protein | 191 | 49% helix, 16% strand | Q9CW03 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 952 | 0.78 | 0.81 | 81 | empty |
| 2 | 111 | 0.40 | 0.75 | 21 | empty |
| 3 | 54 | 0.33 | 0.77 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1627 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 2WD5 · SMC hinge heterodimer (Mouse) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9CW03 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 3… · a predicted model of the same protein · chain B against A, TM-score 0.95
- Q9CU62 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 1A… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9CU62
- Every structure of UniProt Q9CW03
- Elsewhere: RCSB PDB 2WD5 · PDBe 2WD5 · UniProt Q9CU62 · UniProt Q9CW03
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