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Crystal structure of nonsyndromic deafness (DFNB12) associated mutant D124G of mouse cadherin-23 EC1-2
Analyse Crystal structure of nonsyndromic deafness (DFNB12) associated mutant D124G of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WD0
- Type
- protein
- Length
- 416 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cadherin-23
- UniProt
- Q99PF4
- Ligands
- CA, NA, CL
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Cadherin-23 | protein | 208 | 6% helix, 43% strand | Q99PF4 |
Ligands and binding sites
- CA · Calcium ion · metal · 6 copies · chains A, C
- NA · Sodium ion · metal · 2 copies · chains A, C
- CL · Chloride ion · ion · 3 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–C · 501 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2WD0 · Crystal structure of nonsyndromic deafness (DFNB12) associated mutant D124G of mouse… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99PF4
- Elsewhere: RCSB PDB 2WD0 · PDBe 2WD0 · UniProt Q99PF4
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