Research workbench
Structure of a complex between neisseria meningitidis factor H binding protein and ccps 6-7 of human complement factor H
Analyse Structure of a complex between neisseria meningitidis factor H binding protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2W80
- Type
- protein
- Length
- 1,467 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement factor H; Factor H binding protein
- UniProt
- P08603, Q9JXV4
- Pockets
- 19 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, E, G | Complement factor H | protein | 123 | 8% helix, 37% strand | P08603 |
| C | Factor H binding protein | protein | 243 | 5% helix, 63% strand | Q9JXV4 |
| D, F, H | Factor H binding protein | protein | 244 | 6% helix, 61% strand | Q9JXV4 |
Pockets
19 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.69 | 0.96 | 18 | empty |
| 2 | 55 | 0.67 | 0.96 | 21 | empty |
| 3 | 56 | 0.66 | 0.95 | 18 | empty |
| 4 | 54 | 0.65 | 0.95 | 20 | empty |
| 5 | 477 | 0.60 | 0.74 | 64 | empty |
Interfaces
9 interfaces between chains.
- E–F · 1630 Ų buried · 29 hydrogen bonds · protein-protein
- B–C · 1624 Ų buried · 28 hydrogen bonds · protein-protein
- A–D · 1621 Ų buried · 36 hydrogen bonds · protein-protein
- G–H · 1576 Ų buried · 32 hydrogen bonds · protein-protein
- C–F · 200 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 2W80 · Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs… · the same entry in another collection · chain H against H, TM-score 1.00
- P08603 · AlphaFold monomer V2.0 prediction for complement factor H (P08603) · a predicted model of the same protein · chain B against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08603
- Every structure of UniProt Q9JXV4
- Elsewhere: RCSB PDB 2W80 · PDBe 2W80 · UniProt P08603 · UniProt Q9JXV4
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