Research workbench

Structure of the human line-1 ORF1P central domain

Analyse Structure of the human line-1 ORF1P central domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2W7A
Type: protein
Length: 199 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Line-1 ORF1P
UniProt: Q15605
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Line-1 ORF1P	protein	100	35% helix, 28% strand	Q15605
B	Line-1 ORF1P	protein	99	35% helix, 29% strand	Q15605

Ligands and binding sites

MLI · Malonate ion · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	179	0.57	0.81	21	empty
2	56	0.28	0.74	17	empty

Interfaces

1 interface between chains.

A–B · 615 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

2W7A · Structure of the human LINE-1 ORF1p central domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15605
Elsewhere: RCSB PDB 2W7A · PDBe 2W7A · UniProt Q15605

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.