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Crystal structure of an artificial (BA)8-barrel protein designed from identical half barrels

Analyse Crystal structure of an artificial (BA)8-barrel protein designed from identical… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2W6R
Type: protein
Length: 223 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Imidazole glycerol phosphate synthase subunit hisf
EC: 4.1.3.-
UniProt: Q9X0C6
Pockets: 2 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Imidazole glycerol phosphate synthase subunit hisf (EC 4.1.3.-)	protein	223	30% helix, 33% strand	Q9X0C6

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	471	0.66	0.78	59	empty
2	118	0.43	0.77	23	empty

Compared structures

2W6R · Crystal structure of an artificial (ba)8-barrel protein designed from identical half… · the same entry in another collection · chain A against A, TM-score 1.00
Q9X0C6 · AlphaFold monomer V2.0 prediction for imidazole glycerol phosphate synthase subunit hisf… · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9X0C6
Elsewhere: RCSB PDB 2W6R · PDBe 2W6R · UniProt Q9X0C6

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