Research workbench
Don inactivated escherichia COLI glutamine phosphoribosylpyrophosphate (prpp) amidotransferase
Analyse Don inactivated escherichia COLI glutamine phosphoribosylpyrophosphate (prpp)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ECG
- Type
- protein
- Length
- 992 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamine phosphoribosylpyrophosphate amidotransferase
- EC
- 2.4.2.14
- UniProt
- P00496
- Ligands
- PIN, ONL
- Pockets
- 14 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamine phosphoribosylpyrophosphate amidotransferase (EC 2.4.2.14) | protein | 492 | 34% helix, 23% strand | P00496 |
| B | Glutamine phosphoribosylpyrophosphate amidotransferase (EC 2.4.2.14) | protein | 500 | 35% helix, 24% strand | P00496 |
Ligands and binding sites
- PIN · Piperazine-N,N'-bis(2-ethanesulfonic acid) · ligand · 6 copies · chains A, B
- ONL · 5-oxo-L-norleucine · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 972 | 0.85 | 0.86 | 93 | PIN |
| 2 | 132 | 0.69 | 0.90 | 34 | ONL |
| 3 | 119 | 0.68 | 0.90 | 39 | ONL |
| 4 | 121 | 0.60 | 0.85 | 30 | empty |
| 5 | 248 | 0.59 | 0.79 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 2861 Ų buried · 33 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 covalent (covalent ligand).
Compared structures
- 1ECG · Don inactivated escherichia COLI glutamine phosphoribosylpyrophosphate (prpp)… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00496
- Elsewhere: RCSB PDB 1ECG · PDBe 1ECG · UniProt P00496
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