Research workbench
Isometrically contracting insect asynchronous flight muscle quick frozen after a length step
Analyse Isometrically contracting insect asynchronous flight muscle quick frozen after… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2W4U
- Type
- protein
- Length
- 8,759 residues
- Chains
- 36
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Troponin C, skeletal muscle; Troponin T, fast skeletal muscle isoforms; Troponin I, fast…
- UniProt
- P02588, P12620, P68246, P58772, P68135
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 7 distinct chains · 74% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 0, 3, 6, 9 | Troponin C, skeletal muscle | protein | 159 | 63% helix, 3% strand | P02588 |
| 1, 4, 7, Y | Troponin T, fast skeletal muscle isoforms | protein | 90 | 77% helix, 0% strand | P12620 |
| 2, 5, 8, Z | Troponin I, fast skeletal muscle | protein | 141 | 65% helix, 0% strand | P68246 |
| A | Tropomyosin alpha-1 chain | protein | 260 | 99% helix, 0% strand | P58772 |
| B, U, V | Tropomyosin alpha-1 chain | protein | 277 | 99% helix, 0% strand | P58772 |
| C, T, W, X | Tropomyosin alpha-1 chain | protein | 39 | 95% helix, 0% strand | P58772 |
| D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S | Actin, alpha skeletal muscle | protein | 372 | 42% helix, 20% strand | P68135 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1063 | 0.80 | 0.81 | 109 | empty |
| 2 | 848 | 0.78 | 0.81 | 96 | empty |
| 3 | 977 | 0.78 | 0.80 | 99 | empty |
| 4 | 1073 | 0.78 | 0.80 | 115 | empty |
| 5 | 900 | 0.78 | 0.80 | 93 | empty |
Interfaces
91 interfaces between chains.
- U–V · 7375 Ų buried · 47 hydrogen bonds · protein-protein
- A–B · 6920 Ų buried · 37 hydrogen bonds · protein-protein
- 1–2 · 2423 Ų buried · 21 hydrogen bonds · protein-protein
- 7–8 · 2422 Ų buried · 21 hydrogen bonds · protein-protein
- 4–5 · 2421 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 isopeptide (isopeptide).
Compared structures
- 2W4U · Isometrically contracting insect asynchronous flight muscle quick frozen after a length… · the same entry in another collection · chain 7 against 7, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02588
- Every structure of UniProt P12620
- Every structure of UniProt P68246
- Every structure of UniProt P58772
- Every structure of UniProt P68135
- Elsewhere: RCSB PDB 2W4U · PDBe 2W4U · UniProt P02588 · UniProt P12620 · UniProt P68246 · UniProt P58772 · UniProt P68135
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.