Research workbench
Structure DELTAA1-A4 insulin
Analyse Structure DELTAA1-A4 insulin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2W44
- Type
- protein
- Length
- 136 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin
- UniProt
- A6XGL2
- Ligands
- RCO, ZN, CL
- Pockets
- 3 · best druggability 0.47
Structure
x-ray diffraction · 4 distinct chains · 66% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | Insulin | protein | 17 | 41% helix, 6% strand | A6XGL2 |
| B | Insulin | protein | 29 | 66% helix, 3% strand | A6XGL2 |
| D | Insulin | protein | 28 | 75% helix, 4% strand | A6XGL2 |
| F | Insulin | protein | 28 | 71% helix, 4% strand | A6XGL2 |
Ligands and binding sites
- RCO · Resorcinol · ligand · 3 copies · chains A, B, D, C, F, E
- ZN · Zinc ion · metal · chains B, D, F
- CL · Chloride ion · ion · chains B, D, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.47 | 0.83 | 17 | RCO |
| 2 | 76 | 0.44 | 0.80 | 13 | RCO |
| 3 | 87 | 0.42 | 0.79 | 19 | RCO |
Interfaces
9 interfaces between chains.
- A–B · 648 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 524 Ų buried · 4 hydrogen bonds · protein-protein
- E–F · 500 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 215 Ų buried · 3 hydrogen bonds · protein-protein
- B–F · 161 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 2W44 · Structure DeltaA1-A4 insulin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A6XGL2
- Elsewhere: RCSB PDB 2W44 · PDBe 2W44 · UniProt A6XGL2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.