Research workbench
Crystal structure of the filamin a repeat 21 complexed with the migfilin peptide
Analyse Crystal structure of the filamin a repeat 21 complexed with the migfilin peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2W0P
- Type
- protein
- Length
- 196 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Filamin-a; Filamin-binding lim protein 1
- UniProt
- P21333, Q8WUP2
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 3 distinct chains · 8% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Filamin-a | protein | 93 | 10% helix, 51% strand | P21333 |
| B | Filamin-a | protein | 94 | 6% helix, 50% strand | P21333 |
| C | Filamin-binding lim protein 1 | protein | 9 | 0% helix, 78% strand | Q8WUP2 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 143 | 0.50 | 0.79 | 27 | empty |
| 2 | 93 | 0.36 | 0.75 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–C · 545 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 480 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 367 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2W0P · Crystal structure of the filamin A repeat 21 complexed with the migfilin peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P21333 · AlphaFold monomer V2.0 prediction for filamin-a (P21333) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q8WUP2 · AlphaFold monomer V2.0 prediction for filamin-binding lim protein 1 (Q8WUP2) · a predicted model of the same protein · chain C against A, TM-score 0.42
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21333
- Every structure of UniProt Q8WUP2
- Elsewhere: RCSB PDB 2W0P · PDBe 2W0P · UniProt P21333 · UniProt Q8WUP2
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