Research workbench
Complex between the extracellular domain of erythropoietin (epo) receptor [ebp] and an inactive peptide [EMP33] contains 3,5-dibromotyrosine in position 4 (denoted dby)
Analyse Complex between the extracellular domain of erythropoietin (epo) receptor [ebp]… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1EBA
- Type
- protein
- Length
- 451 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (erythropoietin receptor); Protein (epo mimetics peptide 33)
- UniProt
- P19235
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 3 distinct chains · 9% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (erythropoietin receptor) | protein | 212 | 9% helix, 44% strand | P19235 |
| B | Protein (erythropoietin receptor) | protein | 207 | 10% helix, 43% strand | P19235 |
| C, D | Protein (epo mimetics peptide 33) | protein | 16 | 0% helix, 50% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 213 | 0.57 | 0.80 | 24 | empty |
| 2 | 50 | 0.24 | 0.72 | 12 | empty |
Interfaces
6 interfaces between chains.
- C–D · 416 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 325 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 320 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 240 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 167 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 6 disulfide, 2 modified (disulfide, nonstandard).
Compared structures
- 1EBA · Complex between the extracellular domain of erythropoietin (epo) receptor [ebp] and an… · the same entry in another collection · chain A against A, TM-score 1.00
- P19235 · AlphaFold monomer V2.0 prediction for erythropoietin receptor (P19235) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19235
- Elsewhere: RCSB PDB 1EBA · PDBe 1EBA · UniProt P19235
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.