Research workbench
Solution structure of the seca-signal peptide complex
Analyse Solution structure of the seca-signal peptide complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2VDA
- Type
- protein
- Length
- 856 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translocase subunit seca; Maltoporin
- UniProt
- P10408, Q8CVI4
- Pockets
- 10 · best druggability 0.71
Structure
solution nmr · 2 distinct chains · 52% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Translocase subunit seca | protein | 828 | 53% helix, 11% strand | P10408 |
| B | Maltoporin | protein | 28 | 29% helix, 0% strand | Q8CVI4 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 857 | 0.71 | 0.76 | 70 | empty |
| 2 | 57 | 0.68 | 0.96 | 25 | empty |
| 3 | 390 | 0.67 | 0.80 | 36 | empty |
| 4 | 281 | 0.66 | 0.82 | 48 | empty |
| 5 | 66 | 0.66 | 0.93 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1235 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 2VDA · Solution structure of the SecA-signal peptide complex · the same entry in another collection · chain A against A, TM-score 1.00
- P10408 · AlphaFold monomer V2.0 prediction for protein translocase subunit seca (P10408) · a predicted model of the same protein · chain A against A, TM-score 0.88
- Q8CVI4 · AlphaFold monomer V2.0 prediction for maltoporin (Q8CVI4) · a predicted model of the same protein · chain B against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10408
- Every structure of UniProt Q8CVI4
- Elsewhere: RCSB PDB 2VDA · PDBe 2VDA · UniProt P10408 · UniProt Q8CVI4
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