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Crystal structure of human cardiac calsequestrin

Analyse Crystal structure of human cardiac calsequestrin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2VAF
Type: protein
Length: 349 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calsequestrin-2
UniProt: O14958
Pockets: 9 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calsequestrin-2	protein	349	37% helix, 17% strand	O14958

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	459	0.78	0.86	47	empty
2	255	0.66	0.83	46	empty
3	111	0.56	0.83	18	empty
4	99	0.52	0.83	18	empty
5	79	0.48	0.82	15	empty

Compared structures

2VAF · Crystal structure of Human Cardiac Calsequestrin · the same entry in another collection · chain A against A, TM-score 1.00
O14958 · AlphaFold monomer V2.0 prediction for calsequestrin-2 (O14958) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14958
Elsewhere: RCSB PDB 2VAF · PDBe 2VAF · UniProt O14958

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