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Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine
Analyse Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1E8Y
- Type
- protein
- Length
- 841 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol 3-kinase catalytic subunit
- EC
- 2.7.1.137
- UniProt
- P48736
- Pockets
- 11 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 3-kinase catalytic subunit (EC 2.7.1.137) | protein | 841 | 45% helix, 17% strand | P48736 |
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1154 | 0.80 | 0.81 | 80 | empty |
| 2 | 836 | 0.74 | 0.78 | 73 | empty |
| 3 | 637 | 0.70 | 0.78 | 78 | empty |
| 4 | 54 | 0.67 | 0.96 | 19 | empty |
| 5 | 166 | 0.58 | 0.82 | 29 | empty |
Compared structures
- 1E8Y · Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48736
- Elsewhere: RCSB PDB 1E8Y · PDBe 1E8Y · UniProt P48736
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