Research workbench
Structure of mal-RPEL2 complexed to G-actin
Analyse Structure of mal-RPEL2 complexed to G-actin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2V52
- Type
- protein
- Length
- 390 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, alpha skeletal muscle; MKL/MYOCARDIN-like protein 1
- UniProt
- P68135, Q8K4J6
- Ligands
- LAB, ATP, MG
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Actin, alpha skeletal muscle | protein | 360 | 45% helix, 21% strand | P68135 |
| M | MKL/MYOCARDIN-like protein 1 | protein | 30 | 47% helix, 0% strand | Q8K4J6 |
Ligands and binding sites
- LAB · Latrunculin B · ligand · chains B
- ATP · Adenosine-5'-triphosphate · ligand · chains B
- MG · Magnesium ion · metal · chains B
- GOL · Glycerol · additive · 2 copies · chains B, M
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 380 | 0.73 | 0.84 | 50 | LAB, ATP, MG |
| 2 | 296 | 0.65 | 0.81 | 37 | GOL |
Interfaces
1 interface between chains.
- B–M · 1073 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 2V52 · Structure of MAL-RPEL2 complexed to G-actin · the same entry in another collection · chain B against B, TM-score 1.00
- P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q8K4J6 · AlphaFold monomer V2.0 prediction for myocardin-related transcription factor a (Q8K4J6) · a predicted model of the same protein · chain M against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68135
- Every structure of UniProt Q8K4J6
- Elsewhere: RCSB PDB 2V52 · PDBe 2V52 · UniProt P68135 · UniProt Q8K4J6
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