Research workbench
Human CTP synthetase 2 - glutaminase domain in complex with 5-oxo-L-norleucine
Analyse Human CTP synthetase 2 - glutaminase domain in complex with 5-oxo-L-norleucine in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2V4U
- Type
- protein
- Length
- 267 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CTP synthase 2
- EC
- 6.3.4.2
- UniProt
- Q9NRF8
- Pockets
- 3 · best druggability 0.45
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CTP synthase 2 (EC 6.3.4.2) | protein | 267 | 37% helix, 29% strand | Q9NRF8 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.45 | 0.82 | 16 | empty |
| 2 | 78 | 0.34 | 0.75 | 17 | empty |
| 3 | 72 | 0.32 | 0.74 | 22 | empty |
Modifications
Observed in the structure: 1 modified (nonstandard).
Compared structures
- 2V4U · Human CTP synthetase 2 - glutaminase domain in complex with 5-OXO-L- NORLEUCINE · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NRF8 · AlphaFold monomer V2.0 prediction for CTP synthase 2 (Q9NRF8) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NRF8
- Elsewhere: RCSB PDB 2V4U · PDBe 2V4U · UniProt Q9NRF8
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