Research workbench
Complex of human phosphoinositide 3-kinase catalytic subunit gamma (P110 gamma) with pik-284
Analyse Complex of human phosphoinositide 3-kinase catalytic subunit gamma (P110 gamma)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2V4L
- Type
- protein
- Length
- 844 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- EC
- 2.7.1.153
- UniProt
- P48736
- Ligands
- ABJ
- Pockets
- 14 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) | protein | 844 | 45% helix, 17% strand | P48736 |
Ligands and binding sites
- ABJ · 3-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenol · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1087 | 0.82 | 0.83 | 78 | empty |
| 2 | 103 | 0.77 | 0.98 | 35 | empty |
| 3 | 360 | 0.65 | 0.79 | 37 | ABJ |
| 4 | 342 | 0.64 | 0.79 | 43 | empty |
| 5 | 154 | 0.60 | 0.84 | 23 | empty |
Compared structures
- 2V4L · complex of human phosphoinositide 3-kinase catalytic subunit gamma (p110 gamma) with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48736
- Elsewhere: RCSB PDB 2V4L · PDBe 2V4L · UniProt P48736
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