Research workbench

Human adenylosuccinate synthetase isozyme 2 in complex with GDP

Analyse Human adenylosuccinate synthetase isozyme 2 in complex with GDP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2V40
Type: protein
Length: 419 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adenylosuccinate synthetase isozyme 2
EC: 6.3.4.4
UniProt: P30520
Ligands: GDP
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Adenylosuccinate synthetase isozyme 2 (EC 6.3.4.4)	protein	419	39% helix, 23% strand	P30520

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	989	0.74	0.77	80	GDP

Compared structures

2V40 · Human Adenylosuccinate synthetase isozyme 2 in complex with GDP · the same entry in another collection · chain A against A, TM-score 1.00
P30520 · AlphaFold monomer V2.0 prediction for adenylosuccinate synthetase isozyme 2 (P30520) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30520
Elsewhere: RCSB PDB 2V40 · PDBe 2V40 · UniProt P30520

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