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Structure of a phosphoinositide 3-kinase alpha adaptor- binding domain (abd) in a complex with the ISH2 domain from P85 alpha

Analyse Structure of a phosphoinositide 3-kinase alpha adaptor- binding domain (abd) in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2V1Y
Type
protein
Length
260 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform…
EC
2.7.1.153
UniProt
P32871, P27986

Structure

x-ray diffraction · 2 distinct chains · 67% helix, 12% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
APhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153)protein9026% helix, 36% strandP32871
BPhosphatidylinositol 3-kinase regulatory subunit alpha (EC 2.7.1.153)protein17089% helix, 0% strandP27986

Interfaces

1 interface between chains.

  • A–B · 1193 Ų buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

  • 2V1Y · Structure of a phosphoinositide 3-kinase alpha adaptor-binding domain (ABD) in a complex… · the same entry in another collection · chain A against A, TM-score 1.00
  • P32871 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase… · a predicted model of the same protein · chain A against A, TM-score 0.98

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