Research workbench
Crystal structure of a cbs domain pair from the regulatory GAMMA1 subunit of human ampk in complex with AMP
Analyse Crystal structure of a cbs domain pair from the regulatory GAMMA1 subunit of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2UV6
- Type
- protein
- Length
- 143 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-AMP-activated protein kinase subunit gamma-1
- UniProt
- P54619
- Ligands
- AMP
- Pockets
- 2 · best druggability 0.35
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5'-AMP-activated protein kinase subunit gamma-1 | protein | 143 | 40% helix, 23% strand | P54619 |
Ligands and binding sites
- AMP · Adenosine monophosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 81 | 0.35 | 0.76 | 18 | empty |
| 2 | 54 | 0.34 | 0.78 | 13 | AMP |
Compared structures
- 2UV6 · Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK… · the same entry in another collection · chain A against A, TM-score 1.00
- P54619 · AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase subunit gamma-1… · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54619
- Elsewhere: RCSB PDB 2UV6 · PDBe 2UV6 · UniProt P54619
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