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Structure of UP1-telomeric DNA complex

Analyse Structure of UP1-telomeric DNA complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2UP1
Type: protein + DNA
Length: 194 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (5'-D(P*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'); Protein (heterogeneous nuclear…
UniProt: P09651
Pockets: 1 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	DNA (5'-D(PTPAPGPGPGPTPTPAPGPGP*G)-3')	dna	11	—	—
A	Protein (heterogeneous nuclear ribonucleoprotein A1)	protein	183	28% helix, 33% strand	P09651

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	174	0.52	0.78	22	empty

Interfaces

1 interface between chains.

B–A · 802 Å² buried · 22 hydrogen bonds · protein-nucleic

Compared structures

2UP1 · Structure of UP1-telomeric DNA complex · the same entry in another collection · chain B against B, TM-score 1.00
P09651 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein A1 (P09651) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09651
Elsewhere: RCSB PDB 2UP1 · PDBe 2UP1 · UniProt P09651

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