Crystal structure of an engineered subtilisin inhibitor complexed with bovine trypsin

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 0% strand (DSSP).

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• E–I · 155 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

• 2TLD · Crystal structure of an engineered subtilisin inhibitor complexed with bovine trypsin · the same entry in another collection · chain E against E, TM-score 1.00
• 1TNH · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain E against A, TM-score 0.98
• 1TNJ · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain E against A, TM-score 0.98
• 1TNG · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain E against A, TM-score 0.98
• 1TNI · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain E against A, TM-score 0.98
• 1TNK · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain E against A, TM-score 0.98
• 1TNL · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain E against A, TM-score 0.98
• P01006 · AlphaFold monomer V2.0 prediction for subtilisin inhibitor (P01006) · a predicted model of the same protein · chain I against A, TM-score 0.90

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00760
• Every structure of UniProt P01006
• Elsewhere: RCSB PDB 2TLD · PDBe 2TLD · UniProt P00760 · UniProt P01006