Research workbench
Solution structure of the isolated histone H2A-H2B heterodimer
Analyse Solution structure of the isolated histone H2A-H2B heterodimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2RVQ
- Type
- protein
- Length
- 262 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H2A type 1-B/E; Histone H2B type 1-J
- UniProt
- P04908, P06899
- Pockets
- 1 · best druggability 0.56
Structure
solution nmr · 2 distinct chains · 46% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Histone H2A type 1-B/E | protein | 133 | 41% helix, 2% strand | P04908 |
| D | Histone H2B type 1-J | protein | 129 | 52% helix, 2% strand | P06899 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 174 | 0.56 | 0.80 | 27 | empty |
Interfaces
1 interface between chains.
- C–D · 2665 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 2RVQ · Solution structure of the isolated histone H2A-H2B heterodimer · the same entry in another collection · chain C against C, TM-score 1.00
- P06899 · AlphaFold monomer V2.0 prediction for histone H2B type 1-J (P06899) · a predicted model of the same protein · chain D against A, TM-score 0.61
- P04908 · AlphaFold monomer V2.0 prediction for histone H2A type 1-B/E (P04908) · a predicted model of the same protein · chain C against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04908
- Every structure of UniProt P06899
- Elsewhere: RCSB PDB 2RVQ · PDBe 2RVQ · UniProt P04908 · UniProt P06899
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