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Solution structure of MDA5 ctd

Analyse Solution structure of MDA5 ctd in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2RQB
Type: protein
Length: 135 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interferon-induced helicase C domain-containing protein 1
EC: 3.6.1.-
UniProt: Q9BYX4
Ligands: ZN
Pockets: 2 · best druggability 0.40

Structure

solution nmr · 1 distinct chain · 10% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-)	protein	135	10% helix, 29% strand	Q9BYX4

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.40	0.79	23	empty
2	56	0.32	0.77	16	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2RQB · Solution structure of MDA5 CTD · the same entry in another collection · chain A against A, TM-score 1.00
Q9BYX4 · AlphaFold monomer V2.0 prediction for interferon-induced helicase C domain-containing… · a predicted model of the same protein · chain A against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BYX4
Elsewhere: RCSB PDB 2RQB · PDBe 2RQB · UniProt Q9BYX4

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