UniProt Q9BYX4
Interferon-induced helicase C domain-containing protein 1 (Q9BYX4)
Interferon-induced helicase C domain-containing protein 1 (UniProt Q9BYX4), EC 3.6.4.13: 16 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 79 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9BYX4
- Protein
- Interferon-induced helicase C domain-containing protein 1
- EC
- 3.6.4.13
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 79 · 5 records with a druggable one
Structures
17 records of Q9BYX4 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2RQB | Solution structure of MDA5 CTD | solution nmr | A | — | — |
| 2RQB | Solution structure of MDA5 ctd | solution nmr | A | — | — |
| 3B6E | Crystal structure of human DECH-box RNA Helicase MDA5 (Melanoma differentiation-associated protein… | x-ray diffraction | A | — | — |
| 3B6E | Crystal structure of human dech-box RNA helicase MDA5 (melanoma differentiation-associated protein… | x-ray diffraction | A | — | — |
| 3GA3 | Crystal structure of the C-terminal domain of human MDA5 | x-ray diffraction | A | — | — |
| 3GA3 | Crystal structure of the C-terminal domain of human MDA5 | x-ray diffraction | A | — | — |
| 4GL2 | Structural Basis for dsRNA duplex backbone recognition by MDA5 | x-ray diffraction | A, B | — | — |
| 4GL2 | Structural basis for dsrna duplex backbone recognition by MDA5 | x-ray diffraction | A, B | — | — |
| 7DNI | MDA5 CARDs-MAVS CARD polyUb complex | electron microscopy | A, B, C, D | — | 20 (best 0.89) |
| 7DNI | MDA5 cards-mavs card polyub complex | electron microscopy | A, B, C, D | — | — |
| 7DNJ | K63-polyUb MDA5CARDs complex | electron microscopy | A, B, C, D | — | 15 (best 0.88) |
| 7DNJ | K63-polyub MDA5CARDS complex | electron microscopy | A, B, C, D | — | — |
| 7JL0 | Cryo-EM structure of MDA5-dsRNA in complex with TRIM65 PSpry domain (Monomer) | electron microscopy | A | ZN, ADP, ALF, MG | 12 (best 0.79) |
| 7JL0 | Cryo-EM structure of MDA5-dsrna in complex with TRIM65 pspry domain (monomer) | electron microscopy | A | ZN, ADP, ALF, MG | — |
| 7JL2 | Cryo-EM structure of MDA5-dsRNA filament in complex with TRIM65 PSpry domain (Trimer) | electron microscopy | A, C, E | ZN, ADP, ALF, MG | 17 (best 0.83) |
| 7JL2 | Cryo-EM structure of MDA5-dsrna filament in complex with TRIM65 pspry domain (trimer) | electron microscopy | A, C, E | ZN, ADP, ALF | — |
| Q9BYX4 | AlphaFold monomer V2.0 prediction for interferon-induced helicase C domain-containing protein 1… | predicted | A | — | 15 (best 0.71) |
Ligands
Experiment against prediction
- 4GL2 chain B against the predicted model Q9BYX4: TM-score 0.99, RMSD 1.03 Å
- 4GL2 chain B against the predicted model Q9BYX4: TM-score 0.99, RMSD 1.03 Å
- 4GL2 chain A against the predicted model Q9BYX4: TM-score 0.98, RMSD 1.14 Å
- 4GL2 chain A against the predicted model Q9BYX4: TM-score 0.98, RMSD 1.14 Å
- 7JL0 chain A against the predicted model Q9BYX4: TM-score 0.97, RMSD 1.69 Å
- 7JL0 chain A against the predicted model Q9BYX4: TM-score 0.97, RMSD 1.69 Å
- 7JL2 chain E against the predicted model Q9BYX4: TM-score 0.97, RMSD 1.72 Å
- 7JL2 chain A against the predicted model Q9BYX4: TM-score 0.97, RMSD 1.72 Å
- 7JL2 chain A against the predicted model Q9BYX4: TM-score 0.97, RMSD 1.72 Å
- 7JL2 chain C against the predicted model Q9BYX4: TM-score 0.97, RMSD 1.72 Å
Elsewhere
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