Research workbench
Structure of the C-terminal pid domain of FE65L1 complexed with the cytoplasmic tail of app reveals a novel peptide binding mode
Analyse Structure of the C-terminal pid domain of FE65L1 complexed with the cytoplasmic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ROZ
- Type
- protein
- Length
- 168 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptide from amyloid beta A4 protein; Amyloid beta A4 precursor protein-binding family B…
- UniProt
- P12023, Q9DBR4
Structure
solution nmr · 2 distinct chains · 21% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptide from amyloid beta A4 protein | protein | 32 | 34% helix, 3% strand | P12023 |
| B | Amyloid beta A4 precursor protein-binding family B member 2 | protein | 136 | 18% helix, 30% strand | Q9DBR4 |
Interfaces
1 interface between chains.
- A–B · 883 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 2ROZ · Structure of the C-terminal PID Domain of Fe65L1 Complexed with the Cytoplasmic Tail of… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9DBR4 · AlphaFold monomer V2.0 prediction for amyloid-beta A4 precursor protein-binding family B… · a predicted model of the same protein · chain B against A, TM-score 0.87
- P12023 · AlphaFold monomer V2.0 prediction for amyloid-beta A4 protein (P12023) · a predicted model of the same protein · chain A against A, TM-score 0.38
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12023
- Every structure of UniProt Q9DBR4
- Elsewhere: RCSB PDB 2ROZ · PDBe 2ROZ · UniProt P12023 · UniProt Q9DBR4
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