Research workbench
Solution structure of the VAV1 SH2 domain complexed with a tyrosine- phosphorylated peptide from SLP76
Analyse Solution structure of the VAV1 SH2 domain complexed with a tyrosine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ROR
- Type
- protein
- Length
- 153 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proto-oncogene vav; 15-meric peptide from lymphocyte cytosolic protein 2
- UniProt
- P15498, Q13094
- Pockets
- 2 · best druggability 0.41
Structure
solution nmr · 2 distinct chains · 16% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proto-oncogene vav | protein | 138 | 17% helix, 17% strand | P15498 |
| B | 15-meric peptide from lymphocyte cytosolic protein 2 | protein | 15 | 0% helix, 0% strand | Q13094 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 119 | 0.41 | 0.76 | 23 | empty |
| 2 | 63 | 0.34 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 592 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 2ROR · Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated… · the same entry in another collection · chain A against A, TM-score 1.00
- P15498 · AlphaFold monomer V2.0 prediction for proto-oncogene vav (P15498) · a predicted model of the same protein · chain A against A, TM-score 0.70
- Q13094 · AlphaFold monomer V2.0 prediction for lymphocyte cytosolic protein 2 (Q13094) · a predicted model of the same protein · chain B against A, TM-score 0.18
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15498
- Every structure of UniProt Q13094
- Elsewhere: RCSB PDB 2ROR · PDBe 2ROR · UniProt P15498 · UniProt Q13094
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.