Research workbench
Structural basis of pxxdy motif recognition in SH3 binding
Analyse Structural basis of pxxdy motif recognition in SH3 binding in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ROL
- Type
- protein
- Length
- 76 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epidermal growth factor receptor kinase substrate 8-like protein 1; 12-meric peptide from…
- UniProt
- Q8TE68, P07766
- Pockets
- 1 · best druggability 0.30
Structure
solution nmr · 2 distinct chains · 4% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Epidermal growth factor receptor kinase substrate 8-like protein 1 | protein | 64 | 5% helix, 41% strand | Q8TE68 |
| B | 12-meric peptide from T-cell surface glycoprotein CD3 epsilon chain | protein | 12 | 0% helix, 0% strand | P07766 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.30 | 0.76 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 576 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2ROL · Structural Basis of PxxDY motif recognition in SH3 binding · the same entry in another collection · chain A against A, TM-score 1.00
- Q8TE68 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor kinase substrate… · a predicted model of the same protein · chain A against A, TM-score 0.84
- P07766 · AlphaFold monomer V2.0 prediction for T-cell surface glycoprotein CD3 epsilon chain… · a predicted model of the same protein · chain B against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TE68
- Every structure of UniProt P07766
- Elsewhere: RCSB PDB 2ROL · PDBe 2ROL · UniProt Q8TE68 · UniProt P07766
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