UniProt P07766
T-cell surface glycoprotein CD3 epsilon chain (P07766)
T-cell surface glycoprotein CD3 epsilon chain (UniProt P07766): 24 experimental structures and 1 predicted model on GenesisL1, 45 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P07766
- Protein
- T-cell surface glycoprotein CD3 epsilon chain
- Experimental structures
- 24
- Predicted models
- 1
- Pockets
- 45 · 8 records with a druggable one
Structures
25 records of P07766 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A81 | Crystal structure of the tandem SH2 domain of the syk kinase bound to a dually… | x-ray diffraction | B, D, F, H, J, L | — | — |
| 1A81 | Crystal structure of the tandem SH2 domain of the syk kinase bound to a dually… | x-ray diffraction | B, D, F, H, J, L | — | — |
| 1SY6 | Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment | x-ray diffraction | A | — | — |
| 1SY6 | Crystal structure of CD3GAMMAEPSILON heterodimer in complex with OKT3 Fab fragment | x-ray diffraction | A | — | — |
| 1XIW | Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment | x-ray diffraction | A, E | — | — |
| 1XIW | Crystal structure of human CD3-E/D dimer in complex with a UCHT1 single-chain antibody fragment | x-ray diffraction | A, E | — | — |
| 2JXB | Structure of CD3epsilon-Nck2 first SH3 domain complex | solution nmr | A | — | — |
| 2JXB | Structure of CD3EPSILON-NCK2 first SH3 domain complex | solution nmr | A | — | — |
| 2ROL | Structural Basis of PxxDY motif recognition in SH3 binding | solution nmr | B | — | — |
| 2ROL | Structural basis of pxxdy motif recognition in SH3 binding | solution nmr | B | — | — |
| 6JXR | Structure of human T cell receptor-CD3 complex | electron microscopy | f, e | — | — |
| 6JXR | Structure of human T cell receptor-CD3 complex | electron microscopy | f, e | — | — |
| 7FJD | Cryo-EM structure of a membrane PROTEIN(WT) | electron microscopy | e, f | — | — |
| 7FJE | Cryo-EM structure of a membrane PROTEIN(LL) | electron microscopy | e, f | — | — |
| 7FJF | Cryo-EM structure of a membrane PROTEIN(CS) | electron microscopy | e, f | — | — |
| 7PHR | Structure of a fully assembled T-cell receptor engaging a tumor-associated peptide-MHC I | electron microscopy | E, e | — | 6 (best 0.83) |
| 7PHR | Structure of a fully assembled T-cell receptor engaging a tumor- associated peptide-MHC I | electron microscopy | E, e | — | — |
| 8JC0 | V gamma9 V delta2 TCR and CD3 complex in LMNG | electron microscopy | e, f | — | 4 (best 0.82) |
| 8TW6 | TCR in nanodisc ND-II | electron microscopy | E, F | — | 8 (best 0.81) |
| 8WXE | Vgamma5Vdelta1 EH TCR-CD3 complex | electron microscopy | e, f | — | 7 (best 0.67) |
| 8WY0 | T cell receptor delta 2 gamma 9 with F283A, F290A, and F291A | electron microscopy | e, f | — | 4 (best 0.82) |
| 8WYI | T cell receptor delta 2 gamma 9 with TCRD TM domain chimera of TRAC | electron microscopy | e, f | — | 6 (best 0.82) |
| 8YC0 | T cell receptor V delta2 V gamma9 in GDN | electron microscopy | e, f | — | 5 (best 0.81) |
| 9C3E | TCR - CD3 complex bound to HLA | electron microscopy | E, F | — | 5 (best 0.85) |
| P07766 | AlphaFold monomer V2.0 prediction for T-cell surface glycoprotein CD3 epsilon chain (P07766) | predicted | A | — | — |
Experiment against prediction
- 1XIW chain E against the predicted model P07766: TM-score 0.97, RMSD 0.64 Å
- 1XIW chain E against the predicted model P07766: TM-score 0.97, RMSD 0.64 Å
- 1XIW chain A against the predicted model P07766: TM-score 0.96, RMSD 1.04 Å
- 1XIW chain A against the predicted model P07766: TM-score 0.96, RMSD 1.04 Å
- 8JC0 chain f against the predicted model P07766: TM-score 0.90, RMSD 1.51 Å
- 8WY0 chain f against the predicted model P07766: TM-score 0.89, RMSD 1.54 Å
- 6JXR chain f against the predicted model P07766: TM-score 0.88, RMSD 1.84 Å
- 6JXR chain f against the predicted model P07766: TM-score 0.88, RMSD 1.84 Å
- 9C3E chain F against the predicted model P07766: TM-score 0.88, RMSD 1.81 Å
- 8WYI chain f against the predicted model P07766: TM-score 0.87, RMSD 1.67 Å
Elsewhere
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