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Solution structure of CU(I) human SCO2

Analyse Solution structure of CU(I) human SCO2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2RLI
Type: protein
Length: 170 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SCO2 protein homolog, mitochondrial
UniProt: O43819
Ligands: CU1
Pockets: 3 · best druggability 0.72

Structure

solution nmr · 1 distinct chain · 30% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SCO2 protein homolog, mitochondrial	protein	170	30% helix, 23% strand	O43819

Ligands and binding sites

CU1 · Copper (I) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	328	0.72	0.84	38	empty
2	50	0.60	0.92	16	empty
3	60	0.36	0.78	12	empty

Compared structures

2RLI · Solution structure of Cu(I) human Sco2 · the same entry in another collection · chain A against A, TM-score 1.00
O43819 · AlphaFold monomer V2.0 prediction for protein SCO2 homolog, mitochondrial (O43819) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43819
Elsewhere: RCSB PDB 2RLI · PDBe 2RLI · UniProt O43819

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